A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients

Fernando Valerio Pascua; Oscar Diaz; Rina Medina; Brian Contreras; Jeff Mistroff; Daniel Espinosa; Anupamjeet Sekhon; Diego Paz Handal; Estela Pineda; Miguel Vargas Pineda; Hector Pineda; Maribel Diaz; Anita S. Lewis; Heike Hesse; Miriams T. Castro Lainez; Mark L. Stevens; Miguel Sierra- Hoffman; Sidney C. Ontai; Vincent VanBuren

doi:10.1371/journal.pone.0245025

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Peer-reviewed

Research Article

A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients

Fernando Valerio Pascua ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Critical Care Hospital Leonardo Martínez, San Pedro Sula, Cortés, Honduras

https://orcid.org/0000-0002-5880-7849

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Oscar Diaz ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Critical Care Hospital Regional del Norte Instituto Hondureño de Seguridad Social, San Pedro Sula, Cortés, Honduras

https://orcid.org/0000-0002-5268-3320

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Rina Medina ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras

https://orcid.org/0000-0001-9668-1135

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Brian Contreras ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Detar Family Medicine Residency Program, Texas A&M College of Medicine Victoria, Victoria, TX, United States of America
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Jeff Mistroff ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Detar Family Medicine Residency Program, Texas A&M College of Medicine Victoria, Victoria, TX, United States of America

https://orcid.org/0000-0001-8969-4069

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Daniel Espinosa ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Victoria Hospitalist Associates, Detar Hospital, Victoria, TX, United States of America

https://orcid.org/0000-0002-4231-7300

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Anupamjeet Sekhon ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Detar Family Medicine Residency Program, Texas A&M College of Medicine, Victoria, TX, United States of America
⨯
Diego Paz Handal ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Universidad Nacional Autónoma de Honduras, San Pedro Sula, Cortés, Honduras

https://orcid.org/0000-0001-6481-7181

⨯
Estela Pineda ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Hospital Leonardo Martínez, San Pedro Sula, Cortés, Honduras
⨯
Miguel Vargas Pineda ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Hospital Leonardo Martínez, San Pedro Sula, Cortés, Honduras

https://orcid.org/0000-0001-7912-4011

⨯
Hector Pineda ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Neurology, Hospital Mario Catarino Rivas, San Pedro Sula, Cortés, Honduras

https://orcid.org/0000-0003-3237-3517

⨯
Maribel Diaz ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Allergy and Immunology, Instituto Hondureño de Seguridad Social, Sociedad Hondureña de Inmunología, Tegucigalpa, Honduras

https://orcid.org/0000-0002-3542-3949

⨯
Anita S. Lewis ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Pharmacy Department, El Campo Memorial Hospital, El Campo, TX, United States of America
⨯
Heike Hesse ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Neurology Department, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras
⨯
Miriams T. Castro Lainez ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Facultad de Ciencias Médicas, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras
⨯
Mark L. Stevens ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Research Department, Texas A&M College of Medicine, Detar Family Medicine Residency Program, Victoria, TX, United States of America
⨯
Miguel Sierra- Hoffman ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Research and Infectious Disease Department, Texas A&M College of Medicine, Detar Family Medicine Residency Program, Victoria, TX, United States of America

https://orcid.org/0000-0002-9851-3976

⨯
Sidney C. Ontai ,

Contributed equally to this work with: Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S. Lewis, Heike Hesse, Miriams T. Castro Lainez, Mark L. Stevens, Miguel Sierra- Hoffman, Sidney C. Ontai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Detar Family Medicine Residency Program Department, Texas A&M University College of Medicine, Victoria, TX, United States of America
⨯
[ ... ],
Vincent VanBuren

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: vanburen@tamu.edu

Affiliation Round Rock Clinical Campus, Texas A&M College of Medicine, Round Rock, TX, United States of America

https://orcid.org/0000-0001-7612-6388

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A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients

Fernando Valerio Pascua,
Oscar Diaz,
Rina Medina,
Brian Contreras,
Jeff Mistroff,
Daniel Espinosa,
Anupamjeet Sekhon,
Diego Paz Handal,
Estela Pineda,
Miguel Vargas Pineda

Published: January 7, 2021
https://doi.org/10.1371/journal.pone.0245025

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