Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design

• Sixue Zhang,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Drug Discovery Division, Chemistry Department, Southern Research, Birmingham, Alabama, United States of America

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• Atefeh Garzan,

  Roles Formal analysis, Investigation, Methodology, Resources, Validation, Writing – original draft

  Affiliation Drug Discovery Division, Chemistry Department, Southern Research, Birmingham, Alabama, United States of America

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• Nicole Haese,

  Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America

  https://orcid.org/0000-0003-4871-2763

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• Robert Bostwick,

  Roles Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Drug Discovery Division, High-Throughput Screening Center, Southern Research, Birmingham, Alabama, United States of America

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• Yohanka Martinez-Gzegozewska,

  Roles Investigation, Resources, Validation

  Affiliation Drug Discovery Division, High-Throughput Screening Center, Southern Research, Birmingham, Alabama, United States of America

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• Lynn Rasmussen,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation

  Affiliation Drug Discovery Division, High-Throughput Screening Center, Southern Research, Birmingham, Alabama, United States of America

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• Daniel N. Streblow,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America

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• Mark T. Haise,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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• Ashish K. Pathak,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Drug Discovery Division, Chemistry Department, Southern Research, Birmingham, Alabama, United States of America

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• Corinne E. Augelli-Szafran,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Drug Discovery Division, Chemistry Department, Southern Research, Birmingham, Alabama, United States of America

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• Mousheng Wu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mwu@southernresearch.org

  Affiliation Drug Discovery Division, Chemistry Department, Southern Research, Birmingham, Alabama, United States of America

  https://orcid.org/0000-0001-7285-1363

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