Acute high folic acid treatment in SH-SY5Y cells with and without MTHFR function leads to gene expression changes in epigenetic modifying enzymes, changes in epigenetic marks, and changes in dendritic spine densities

• Daniel F. Clark,

  Roles Formal analysis, Funding acquisition, Investigation

  Affiliation Division of Natural Sciences and Engineering, University of South Carolina Upstate, Spartanburg, South Carolina, United States of America

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• Rachael Schmelz,

  Roles Formal analysis, Funding acquisition, Investigation

  Affiliation Division of Natural Sciences and Engineering, University of South Carolina Upstate, Spartanburg, South Carolina, United States of America

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• Nicole Rogers,

  Roles Formal analysis, Investigation

  Affiliation Division of Natural Sciences and Engineering, University of South Carolina Upstate, Spartanburg, South Carolina, United States of America

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• Nuri E. Smith,

  Roles Formal analysis, Investigation

  Current address: Lieber Institute for Brain Development, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

  Affiliation Division of Natural Sciences and Engineering, University of South Carolina Upstate, Spartanburg, South Carolina, United States of America

  https://orcid.org/0000-0002-8019-2086

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• Kimberly R. Shorter

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: shortekr@uscupstate.edu

  Affiliation Division of Natural Sciences and Engineering, University of South Carolina Upstate, Spartanburg, South Carolina, United States of America

  https://orcid.org/0000-0001-6117-7940

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