Whole-genome sequence analysis and comparisons between drug-resistance mutations and minimum inhibitory concentrations of Mycobacterium tuberculosis isolates causing M/XDR-TB

Ditthawat Nonghanphithak; Orawee Kaewprasert; Pratchakan Chaiyachat; Wipa Reechaipichitkul; Angkana Chaiprasert; Kiatichai Faksri

doi:10.1371/journal.pone.0244829

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Open Access

Peer-reviewed

Research Article

Whole-genome sequence analysis and comparisons between drug-resistance mutations and minimum inhibitory concentrations of Mycobacterium tuberculosis isolates causing M/XDR-TB

Ditthawat Nonghanphithak,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliations Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen, Thailand
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Orawee Kaewprasert,

Roles Investigation

Affiliations Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen, Thailand
⨯
Pratchakan Chaiyachat,

Roles Investigation

Affiliations Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen, Thailand
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Wipa Reechaipichitkul,

Roles Methodology, Validation, Writing – review & editing

Affiliations Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen, Thailand, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
⨯
Angkana Chaiprasert,

Roles Funding acquisition, Project administration, Resources, Validation, Writing – review & editing

Affiliation Drug Resistant Tuberculosis Research Fund Laboratory, Research and Development Affairs, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
⨯
Kiatichai Faksri

Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: kiatichai@kku.ac.th

Affiliations Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen, Thailand

https://orcid.org/0000-0001-5022-4182

⨯

Whole-genome sequence analysis and comparisons between drug-resistance mutations and minimum inhibitory concentrations of Mycobacterium tuberculosis isolates causing M/XDR-TB

Ditthawat Nonghanphithak,
Orawee Kaewprasert,
Pratchakan Chaiyachat,
Wipa Reechaipichitkul,
Angkana Chaiprasert,
Kiatichai Faksri

Published: December 31, 2020
https://doi.org/10.1371/journal.pone.0244829

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Mycobacterium tuberculosis
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Extensively drug-resistant tuberculosis
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Mutation databases
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Tuberculosis
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Phylogenetic analysis
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Genomics
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Single nucleotide polymorphisms
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Streptomycin
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