Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library

• Hidenori Yano ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: yano.hidenori.kb@daiichisankyo.co.jp

  Affiliations Modality Research Laboratories, Biologics Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan, Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan

  https://orcid.org/0000-0002-1686-4319

  ⨯
• Daisuke Nishimiya,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Modality Research Laboratories, Biologics Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan

  ⨯
• Yoshirou Kawaguchi,

  Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Modality Research Laboratories, Biologics Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan

  ⨯
• Masakazu Tamura,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Modality Research Laboratories, Biologics Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan

  ⨯
• Ryuji Hashimoto

  Roles Conceptualization, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Modality Research Laboratories, Biologics Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan

  ⨯