Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis

Melanie Anger; Florian Scheufele; Deepak Ramanujam; Kathleen Meyer; Hidehiro Nakajima; Loren J. Field; Stefan Engelhardt; Antonio Sarikas

doi:10.1371/journal.pone.0244096

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Open Access

Peer-reviewed

Research Article

Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis

Melanie Anger ,

Contributed equally to this work with: Melanie Anger, Florian Scheufele

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Writing – review & editing

Affiliations Institute of Pharmacology and Toxicology, Technische Universität München, Munich, Germany, German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany
⨯
Florian Scheufele ,

Contributed equally to this work with: Melanie Anger, Florian Scheufele

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Writing – review & editing

Affiliations Institute of Pharmacology and Toxicology, Technische Universität München, Munich, Germany, German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany
⨯
Deepak Ramanujam,

Roles Data curation, Formal analysis, Methodology, Visualization

Affiliations Institute of Pharmacology and Toxicology, Technische Universität München, Munich, Germany, German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany

https://orcid.org/0000-0003-4854-6355

⨯
Kathleen Meyer,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – review & editing

Current address: Cellular Plasticity and Disease Group, Institute for Research in Biomedicine, Barcelona, Spain

Affiliations Institute of Pharmacology and Toxicology, Technische Universität München, Munich, Germany, German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany
⨯
Hidehiro Nakajima,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Wells Center for Pediatric Research and Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Loren J. Field,

Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Wells Center for Pediatric Research and Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Stefan Engelhardt,

Roles Conceptualization, Writing – review & editing

Affiliations Institute of Pharmacology and Toxicology, Technische Universität München, Munich, Germany, German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany
⨯
Antonio Sarikas

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: antonio.sarikas@pmu.ac.at

Affiliation Institute of Pharmacology and Toxicology, Paracelsus Medical University, Salzburg, Austria

https://orcid.org/0000-0003-4807-1206

⨯

Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis

Melanie Anger,
Florian Scheufele,
Deepak Ramanujam,
Kathleen Meyer,
Hidehiro Nakajima,
Loren J. Field,
Stefan Engelhardt,
Antonio Sarikas

Published: December 22, 2020
https://doi.org/10.1371/journal.pone.0244096

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Mouse models
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Fibrosis
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Ubiquitin ligases
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