Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms

Haley S. Province; Cuiying Xiao; Allison S. Mogul; Ankita Sahoo; Kenneth A. Jacobson; Ramón A. Piñol; Oksana Gavrilova; Marc L. Reitman

doi:10.1371/journal.pone.0243986

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Open Access

Peer-reviewed

Research Article

Activation of neuronal adenosine A₁ receptors causes hypothermia through central and peripheral mechanisms

Haley S. Province ,

Contributed equally to this work with: Haley S. Province, Cuiying Xiao

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America
⨯
Cuiying Xiao ,

Contributed equally to this work with: Haley S. Province, Cuiying Xiao

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America
⨯
Allison S. Mogul,

Roles Investigation, Writing – review & editing

Affiliation Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America
⨯
Ankita Sahoo,

Roles Investigation, Writing – review & editing

Affiliation Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America
⨯
Kenneth A. Jacobson,

Roles Writing – review & editing

Affiliation Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America

https://orcid.org/0000-0001-8104-1493

⨯
Ramón A. Piñol,

Roles Investigation, Writing – review & editing

Affiliation Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America
⨯
Oksana Gavrilova,

Roles Investigation, Writing – review & editing

Affiliation Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America
⨯
Marc L. Reitman

Roles Conceptualization, Visualization, Writing – original draft, Writing – review & editing

* E-mail: marc.reitman@nih.gov

Affiliation Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America

https://orcid.org/0000-0002-0426-9475

⨯

Activation of neuronal adenosine A₁ receptors causes hypothermia through central and peripheral mechanisms

Haley S. Province,
Cuiying Xiao,
Allison S. Mogul,
Ankita Sahoo,
Kenneth A. Jacobson,
Ramón A. Piñol,
Oksana Gavrilova,
Marc L. Reitman

Published: December 16, 2020
https://doi.org/10.1371/journal.pone.0243986

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Hypothermia
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Neurons
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Adenosine
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Hypothalamus
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