Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

• Paul B. Finn ,

  Contributed equally to this work with: Paul B. Finn, Devesh Bhimsaria

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: pbfinn@stanford.edu (PBF); dervan@caltech.edu (PBD)

  Current address: Department of Bioengineering, Stanford University, Stanford, California, United States of America

  Affiliation Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America

  https://orcid.org/0000-0002-1253-1314

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• Devesh Bhimsaria ,

  Contributed equally to this work with: Paul B. Finn, Devesh Bhimsaria

  Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Bio Informaticals, Jaipur, Rajasthan, India

  https://orcid.org/0000-0001-8413-3801

  ⨯
• Asfa Ali,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

  ⨯
• Asuka Eguchi,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America

  https://orcid.org/0000-0003-3010-0275

  ⨯
• Aseem Z. Ansari,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Peter B. Dervan

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: pbfinn@stanford.edu (PBF); dervan@caltech.edu (PBD)

  Affiliation Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America

  https://orcid.org/0000-0001-8852-7306

  ⨯