A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction

Simon Lebek; Philipp Hegner; Christian Schach; Kathrin Reuthner; Maria Tafelmeier; Lars Siegfried Maier; Michael Arzt; Stefan Wagner

doi:10.1371/journal.pone.0243844

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Open Access

Peer-reviewed

Research Article

A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction

Simon Lebek,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany

https://orcid.org/0000-0003-4525-797X

⨯
Philipp Hegner,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany

https://orcid.org/0000-0003-1776-777X

⨯
Christian Schach,

Roles Conceptualization, Data curation, Investigation, Methodology, Resources

Affiliation Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
⨯
Kathrin Reuthner,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
⨯
Maria Tafelmeier,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
⨯
Lars Siegfried Maier,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Software, Supervision, Writing – review & editing

Affiliation Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
⨯
Michael Arzt,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

Affiliation Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
⨯
Stefan Wagner

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

* E-mail: stefan.wagner@ukr.de

Affiliation Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
⨯

A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction

Simon Lebek,
Philipp Hegner,
Christian Schach,
Kathrin Reuthner,
Maria Tafelmeier,
Lars Siegfried Maier,
Michael Arzt,
Stefan Wagner

Published: December 10, 2020
https://doi.org/10.1371/journal.pone.0243844

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