Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs

• Ryuta Shioi,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  ⨯
• Fumika Karaki,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Current address: Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University, Shirokane, Minato-ku, Tokyo, Japan

  Affiliation Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  https://orcid.org/0000-0002-3815-713X

  ⨯
• Hiromasa Yoshioka,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  https://orcid.org/0000-0002-9281-9982

  ⨯
• Tomomi Noguchi-Yachide,

  Roles Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  ⨯
• Minoru Ishikawa,

  Roles Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Graduate School of Life Sciences, Tohoku University, Aoba-ku, Sendai, Japan

  ⨯
• Kosuke Dodo,

  Roles Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan

  https://orcid.org/0000-0001-6008-2915

  ⨯
• Yuichi Hashimoto,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  ⨯
• Mikiko Sodeoka,

  Roles Conceptualization, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan

  ⨯
• Kenji Ohgane

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ohgane@rs.tus.ac.jp

  Current address: Department of Applied Bioscience, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

  Affiliations Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan

  https://orcid.org/0000-0003-0565-6503

  ⨯