Missing value imputation in proximity extension assay-based targeted proteomics data

• Michael Lenz ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  * E-mail: michael.l.lenz@gmail.com

  Affiliations Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany, Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

  https://orcid.org/0000-0002-6319-6480

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• Andreas Schulz,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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• Thomas Koeck,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany

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• Steffen Rapp,

  Roles Investigation, Writing – review & editing

  Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany

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• Markus Nagler,

  Roles Investigation, Writing – review & editing

  Affiliation Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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• Madeleine Sauer,

  Roles Investigation, Writing – review & editing

  Affiliation Disease Genomics, Bayer AG, Wuppertal, Germany

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• Lisa Eggebrecht,

  Roles Investigation, Writing – review & editing

  Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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• Vincent Ten Cate,

  Roles Investigation, Writing – review & editing

  Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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• Marina Panova-Noeva,

  Roles Investigation, Writing – review & editing

  Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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• Jürgen H. Prochaska,

  Roles Investigation, Writing – review & editing

  Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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• Karl J. Lackner,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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• Thomas Münzel,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany, Center for Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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• Kirsten Leineweber,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Disease Genomics, Bayer AG, Wuppertal, Germany

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• Philipp S. Wild ,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft

  ¶‡ These authors share last authorship on this work.

  Affiliations Preventive Cardiology and Preventive Medicine–Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, Mainz, Germany, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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• Miguel A. Andrade-Navarro

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft

  ¶‡ These authors share last authorship on this work.

  Affiliation Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany

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