Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury: A CENTER-TBI high-resolution group study

• Cecilia AI Åkerlund ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: cecilia.akerlund@sll.se

  ¶‡ These authors also contributed to the analysis of the data.

  Affiliations Department of Physiology and Pharmacology, Section of Perioperative Medicine and Intensive Care, Karolinska Institutet, Stockholm, Sweden, School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden

  https://orcid.org/0000-0003-4918-1482

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• Joseph Donnelly ,

  Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – review & editing

  ¶‡ These authors also contributed to the analysis of the data.

  Affiliation Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom

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• Frederick A. Zeiler ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Data curation, Writing – review & editing

  Affiliations Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada, Department of Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada, Biomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, Manitoba, Canada, Centre on Aging, University of Manitoba, Winnipeg, Manitoba, Canada, Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom

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• Raimund Helbok ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Neurology, Neurological Intensive Care Unit, Medical University of Innsbruck, Innsbruck, Austria

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• Anders Holst ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ These authors also contributed to the analysis of the data.

  Affiliation School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden

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• Manuel Cabeleira ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Data curation, Writing – review & editing

  Affiliation Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom

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• Fabian Güiza ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Methodology, Writing – review & editing

  Affiliation Department and Laboratory of Intensive Care Medicine, University Hospitals Leuven and KU Leuven, Leuven, Belgium

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• Geert Meyfroidt ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Methodology, Writing – review & editing

  Affiliation Department and Laboratory of Intensive Care Medicine, University Hospitals Leuven and KU Leuven, Leuven, Belgium

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• Marek Czosnyka ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Conceptualization, Software, Writing – review & editing

  Affiliations Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom, Institute of Electronic Systems, Warsaw University of Technolology, Warszawa, Poland

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• Peter Smielewski ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Conceptualization, Software, Writing – review & editing

  Affiliation Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom

  https://orcid.org/0000-0001-5096-3938

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• Nino Stocchetti ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Pathophysiology and Transplants, University of Milan, and Neuroscience Intensive Care Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy

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• Ari Ercole ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ These authors also contributed to the analysis of the data.

  Affiliation Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom

  https://orcid.org/0000-0001-8350-8093

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• David W. Nelson ,

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

  ¶‡ These authors also contributed to the analysis of the data.

  Affiliation Department of Physiology and Pharmacology, Section of Perioperative Medicine and Intensive Care, Karolinska Institutet, Stockholm, Sweden

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• the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  Contributed equally to this work with: Cecilia AI Åkerlund, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators

  ¶A full list of the HR ICU Sub-Study Participants and Investigators is listed in the Acknowledgments.

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