Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model

DaWon Kim; Jeong Hwa Lee; Hye Yun Kim; Jisu Shin; Kyeonghwan Kim; Sejin Lee; Jinwoo Park; JinIkyon Kim; YoungSoo Kim

doi:10.1371/journal.pone.0243041

Loading metrics

Open Access

Peer-reviewed

Research Article

Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model

DaWon Kim ,

Contributed equally to this work with: DaWon Kim, Jeong Hwa Lee

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacy and Yonsei Institute of Pharmaceutical Science, College of Pharmacy, Yonsei University, Incheon, Republic of Korea
⨯
Jeong Hwa Lee ,

Contributed equally to this work with: DaWon Kim, Jeong Hwa Lee

Roles Resources, Writing – original draft

Affiliation Department of Pharmacy and Yonsei Institute of Pharmaceutical Science, College of Pharmacy, Yonsei University, Incheon, Republic of Korea
⨯
Hye Yun Kim,

Roles Writing – review & editing

Affiliation Department of Pharmacy and Yonsei Institute of Pharmaceutical Science, College of Pharmacy, Yonsei University, Incheon, Republic of Korea

https://orcid.org/0000-0003-3757-5652

⨯
Jisu Shin,

Roles Data curation, Resources

Affiliation Department of Pharmacy and Yonsei Institute of Pharmaceutical Science, College of Pharmacy, Yonsei University, Incheon, Republic of Korea
⨯
Kyeonghwan Kim,

Roles Resources

Affiliation Department of Pharmacy and Yonsei Institute of Pharmaceutical Science, College of Pharmacy, Yonsei University, Incheon, Republic of Korea
⨯
Sejin Lee,

Roles Resources

Affiliation Department of Pharmacy and Yonsei Institute of Pharmaceutical Science, College of Pharmacy, Yonsei University, Incheon, Republic of Korea
⨯
Jinwoo Park,

Roles Validation

Affiliation BioActs, Incheon, Republic of Korea
⨯
JinIkyon Kim ,

Roles Resources

* E-mail: ikyonkim@yonsei.ac.kr (JK); y.kim@yonsei.ac.kr (YK)

Affiliation Department of Pharmacy and Yonsei Institute of Pharmaceutical Science, College of Pharmacy, Yonsei University, Incheon, Republic of Korea
⨯
YoungSoo Kim

Roles Investigation

* E-mail: ikyonkim@yonsei.ac.kr (JK); y.kim@yonsei.ac.kr (YK)

Affiliation Department of Pharmacy and Yonsei Institute of Pharmaceutical Science, College of Pharmacy, Yonsei University, Incheon, Republic of Korea

https://orcid.org/0000-0001-5029-7082

⨯

Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model

DaWon Kim,
Jeong Hwa Lee,
Hye Yun Kim,
Jisu Shin,
Kyeonghwan Kim,
Sejin Lee,
Jinwoo Park,
JinIkyon Kim,
YoungSoo Kim

Published: December 23, 2020
https://doi.org/10.1371/journal.pone.0243041

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Fluorescence
Is the Subject Area "Fluorescence" applicable to this article?

Thanks for your feedback.
Oligomers
Is the Subject Area "Oligomers" applicable to this article?

Thanks for your feedback.
Monomers
Is the Subject Area "Monomers" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Dimers
Is the Subject Area "Dimers" applicable to this article?

Thanks for your feedback.
Hippocampus
Is the Subject Area "Hippocampus" applicable to this article?

Thanks for your feedback.
Alzheimer's disease
Is the Subject Area "Alzheimer's disease" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.