Autoclave treatment of the classical scrapie agent US No. 13-7 and experimental inoculation to susceptible VRQ/ARQ sheep via the oral route results in decreased transmission efficiency

• Eric D. Cassmann ,

  Contributed equally to this work with: Eric D. Cassmann, Najiba Mammadova

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, United States of America

  https://orcid.org/0000-0002-7130-2650

  ⨯
• Najiba Mammadova ,

  Contributed equally to this work with: Eric D. Cassmann, Najiba Mammadova

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, United States of America

  ⨯
• Justin J. Greenlee

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: justin.greenlee@usda.gov

  Affiliation Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, United States of America

  https://orcid.org/0000-0003-2202-3054

  ⨯