In silico immune infiltration profiling combined with functional enrichment analysis reveals a potential role for naïve B cells as a trigger for severe immune responses in the lungs of COVID-19 patients

• Yi-Ying Wu,

  Roles Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliation Division of Hematology and Oncology Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (R.O.C.)

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• Sheng-Huei Wang,

  Roles Conceptualization, Investigation, Writing – original draft

  Affiliations Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (R.O.C.), Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan (R.O.C.)

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• Chih-Hsien Wu,

  Roles Data curation, Formal analysis, Validation

  Affiliation Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan (R.O.C.)

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• Li-Chen Yen,

  Roles Formal analysis, Validation, Visualization

  Affiliation Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan (R.O.C.)

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• Hsing-Fan Lai,

  Roles Data curation, Formal analysis, Validation

  Affiliations Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan (R.O.C.), Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan (R.O.C.)

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• Ching-Liang Ho,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Division of Hematology and Oncology Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (R.O.C.)

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• Yi-Lin Chiu

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: yc566@georgetown.edu

  Affiliation Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan (R.O.C.)

  https://orcid.org/0000-0002-1827-6924

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