High-dose naloxone: Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design

• Anders Deichmann Springborg ,

  Roles Formal analysis, Investigation, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: andersspringborg@gmail.com

  Affiliation Neuroscience Center, Copenhagen University Hospitals, Copenhagen, Denmark

  https://orcid.org/0000-0003-2203-7050

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• Elisabeth Kjær Jensen,

  Roles Investigation, Project administration, Resources, Writing – review & editing

  Affiliation Neuroscience Center, Copenhagen University Hospitals, Copenhagen, Denmark

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• Mads Kreilgaard,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Morten Aagaard Petersen,

  Roles Formal analysis, Supervision, Validation, Writing – review & editing

  Affiliation The Research Unit, Department of Palliative Medicine, Copenhagen University Hospitals, Copenhagen, Denmark

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• Theodoros Papathanasiou,

  Roles Formal analysis, Validation, Writing – review & editing

  Affiliation Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Trine Meldgaard Lund,

  Roles Supervision, Validation, Writing – review & editing

  Affiliation Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

  https://orcid.org/0000-0001-8598-2880

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• Bradley Kenneth Taylor,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Department of Anesthesiology, Pittsburgh Center for Pain Research, and the Pittsburgh Project to End Opioid Misuse, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Mads Utke Werner

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Neuroscience Center, Copenhagen University Hospitals, Copenhagen, Denmark, Department of Clinical Sciences, Lund University, Lund, Sweden

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