Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels

Cynthia Al Hageh; Ryan Rahy; Georges Khazen; Francois Brial; Rony S. Khnayzer; Dominique Gauguier; Pierre A. Zalloua

doi:10.1371/journal.pone.0242019

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Peer-reviewed

Research Article

Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels

Cynthia Al Hageh,

Roles Formal analysis, Investigation

Affiliations Université de Paris, INSERM UMRS 1124, Paris, France, Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon
⨯
Ryan Rahy,

Roles Formal analysis

Affiliation Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon
⨯
Georges Khazen,

Roles Data curation, Formal analysis

Affiliation Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon
⨯
Francois Brial,

Roles Formal analysis, Investigation

Affiliation Université de Paris, INSERM UMRS 1124, Paris, France
⨯
Rony S. Khnayzer ,

Contributed equally to this work with: Rony S. Khnayzer, Dominique Gauguier, Pierre A. Zalloua

Roles Conceptualization, Funding acquisition, Resources, Supervision

* E-mail: dominique.gauguier@inserm.fr (DG); rony.khnayzer@lau.edu.lb (RSK); pierre.zalloua@balamand.edu.lb (PAZ)

Affiliation Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon
⨯
Dominique Gauguier ,

Contributed equally to this work with: Rony S. Khnayzer, Dominique Gauguier, Pierre A. Zalloua

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Supervision, Writing – original draft

* E-mail: dominique.gauguier@inserm.fr (DG); rony.khnayzer@lau.edu.lb (RSK); pierre.zalloua@balamand.edu.lb (PAZ)

Affiliations Université de Paris, INSERM UMRS 1124, Paris, France, McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada

https://orcid.org/0000-0001-6156-9530

⨯
Pierre A. Zalloua

Contributed equally to this work with: Rony S. Khnayzer, Dominique Gauguier, Pierre A. Zalloua

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft

* E-mail: dominique.gauguier@inserm.fr (DG); rony.khnayzer@lau.edu.lb (RSK); pierre.zalloua@balamand.edu.lb (PAZ)

Affiliation School of Medicine, University of Balamand, Amioun, Lebanon
⨯

Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels

Cynthia Al Hageh,
Ryan Rahy,
Georges Khazen,
Francois Brial,
Rony S. Khnayzer,
Dominique Gauguier,
Pierre A. Zalloua

Published: November 25, 2020
https://doi.org/10.1371/journal.pone.0242019

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