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Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba
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Logan Tillery ,
Contributed equally to this work with: Logan Tillery, Kayleigh Barrett
Roles Formal analysis, Investigation, Writing – original draft
Affiliations Department of Medicine, Division Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID) University of Washington, Seattle, Washington, United States of America, Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America
⨯ - Kayleigh Barrett ,
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Jenna Goldstein ,
Roles Writing – original draft
¶‡ JG, JWL, BO, NLT, LX and RMY also contributed equally to this work.
Affiliation Department of Biology, Washington University, St. Louis, Missouri, United States of America
⨯ -
Jared W. Lassner ,
Roles Writing – original draft
¶‡ JG, JWL, BO, NLT, LX and RMY also contributed equally to this work.
Affiliation Department of Biology, Washington University, St. Louis, Missouri, United States of America
⨯ - Bram Osterhout ,
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Nathan L. Tran ,
Roles Writing – original draft
¶‡ JG, JWL, BO, NLT, LX and RMY also contributed equally to this work.
Affiliation Department of Biology, Washington University, St. Louis, Missouri, United States of America
⨯ - Lily Xu ,
- Ryan M. Young ,
- Justin Craig,
- Ian Chun,
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David M. Dranow,
Roles Data curation, Investigation, Writing – review & editing
Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America
⨯ -
Jan Abendroth,
Roles Data curation, Investigation, Writing – review & editing
Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America
⨯ -
Silvia L. Delker,
Roles Data curation, Investigation
Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America
⨯ -
Douglas R. Davies,
Roles Data curation, Investigation
Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America
⨯ -
Stephen J. Mayclin,
Roles Data curation, Investigation
Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America
⨯ - Brandy Calhoun,
- Madison J. Bolejack,
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Bart Staker,
Roles Writing – review & editing
Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, Seattle Children’s Research Institute, Seattle, Washington, United States of America
⨯ - Sandhya Subramanian,
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Isabelle Phan,
Roles Investigation, Writing – review & editing
Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, Seattle Children’s Research Institute, Seattle, Washington, United States of America
⨯ -
Donald D. Lorimer,
Roles Data curation, Investigation, Writing – review & editing
Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, UCB Pharma, Bainbridge Island, Washington, United States of America
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Peter J. Myler,
Roles Writing – review & editing
Affiliations Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, Seattle Children’s Research Institute, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Department of Biomedical Informatics & Medical Education, University of Washington, Seattle, Washington, United States of America, Department of Global Health (Pathobiology), University of Washington, Seattle, Washington, United States of America
⨯ - Thomas E. Edwards,
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Dennis E. Kyle,
Roles Investigation, Writing – review & editing
Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
⨯ -
Christopher A. Rice,
Roles Investigation, Writing – review & editing
Current address: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia, United States of America
Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
⨯ -
James C. Morris,
Roles Investigation, Writing – review & editing
Affiliation Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America
⨯ -
James W. Leahy,
Roles Investigation, Writing – review & editing
Affiliation Department of Chemistry, University of South Florida, Tampa, Florida, United States of America
⨯ -
Roman Manetsch,
Roles Investigation, Writing – review & editing
Affiliation Department of Chemistry and Chemical Biology and Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts, United States of America
⨯ - Lynn K. Barrett,
- Craig L. Smith,
- [ ... ],
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Wesley C. Van Voorhis
Roles Formal analysis, Writing – original draft
* E-mail: wesley@u.washington.edu
Affiliations Department of Medicine, Division Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Disease (CERID) University of Washington, Seattle, Washington, United States of America, Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, United States of America, Department of Global Health (Pathobiology), University of Washington, Seattle, Washington, United States of America
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https://orcid.org/0000-0002-5431-3489
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba
- Logan Tillery,
- Kayleigh Barrett,
- Jenna Goldstein,
- Jared W. Lassner,
- Bram Osterhout,
- Nathan L. Tran,
- Lily Xu,
- Ryan M. Young,
- Justin Craig,
- Ian Chun
- Published: March 24, 2021
- https://doi.org/10.1371/journal.pone.0241738
- See the preprint