In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate as a topical treatment for equine skin cancer

Lisa Annabel Weber; Anne Funtan; Reinhard Paschke; Julien Delarocque; Jutta Kalbitz; Jessica Meißner; Karsten Feige; Manfred Kietzmann; Jessika-Maximiliane V. Cavalleri

doi:10.1371/journal.pone.0241448

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Open Access

Peer-reviewed

Research Article

In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate as a topical treatment for equine skin cancer

Lisa Annabel Weber,

Roles Formal analysis, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliation Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany

https://orcid.org/0000-0001-6185-1595

⨯
Anne Funtan,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Biozentrum, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
⨯
Reinhard Paschke,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Biozentrum, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
⨯
Julien Delarocque,

Roles Formal analysis, Visualization

Affiliation Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany

https://orcid.org/0000-0002-4598-3499

⨯
Jutta Kalbitz,

Roles Investigation, Methodology

Affiliation BioSolutions Halle GmbH, Halle (Saale), Germany
⨯
Jessica Meißner,

Roles Conceptualization, Supervision

Affiliation Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
⨯
Karsten Feige,

Roles Funding acquisition, Supervision

Affiliation Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
⨯
Manfred Kietzmann,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
⨯
Jessika-Maximiliane V. Cavalleri

Roles Conceptualization, Funding acquisition, Project administration, Supervision

* E-mail: Jessika.Cavalleri@vetmeduni.ac.at

Affiliation Equine Internal Medicine, University Equine Clinic, University of Veterinary Medicine Vienna, Vienna, Austria
⨯

In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate as a topical treatment for equine skin cancer

Lisa Annabel Weber,
Anne Funtan,
Reinhard Paschke,
Julien Delarocque,
Jutta Kalbitz,
Jessica Meißner,
Karsten Feige,
Manfred Kietzmann,
Jessika-Maximiliane V. Cavalleri

Published: November 5, 2020
https://doi.org/10.1371/journal.pone.0241448

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Equines
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Apoptosis
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Fibroblasts
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Horses
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