A multivariate, quantitative assay that disentangles key kinetic parameters of primary human T cell function in vitro

Grace L. Huang; Daniel P. Nampe; Jason Yi; Grant B. Gabrelow; Kathleen R. Negri; Alexander Kamb; Han Xu

doi:10.1371/journal.pone.0241421

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Open Access

Peer-reviewed

Research Article

A multivariate, quantitative assay that disentangles key kinetic parameters of primary human T cell function in vitro

Grace L. Huang ,

Contributed equally to this work with: Grace L. Huang, Daniel P. Nampe

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Discovery Research, A2 Biotherapeutics, Inc., Agoura Hills, California, United States of America
⨯
Daniel P. Nampe ,

Contributed equally to this work with: Grace L. Huang, Daniel P. Nampe

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Discovery Research, A2 Biotherapeutics, Inc., Agoura Hills, California, United States of America
⨯
Jason Yi,

Roles Investigation, Methodology

Current address: ImmPACT-Bio, Inc., Camarillo, California, United States of America

Affiliation Discovery Research, A2 Biotherapeutics, Inc., Agoura Hills, California, United States of America
⨯
Grant B. Gabrelow,

Roles Investigation

Affiliation Discovery Research, A2 Biotherapeutics, Inc., Agoura Hills, California, United States of America
⨯
Kathleen R. Negri,

Roles Investigation

Affiliation Discovery Research, A2 Biotherapeutics, Inc., Agoura Hills, California, United States of America
⨯
Alexander Kamb,

Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Discovery Research, A2 Biotherapeutics, Inc., Agoura Hills, California, United States of America
⨯
Han Xu

Roles Conceptualization, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hxu@a2biotherapeutics.com

Affiliation Discovery Research, A2 Biotherapeutics, Inc., Agoura Hills, California, United States of America

https://orcid.org/0000-0002-1530-2162

⨯

A multivariate, quantitative assay that disentangles key kinetic parameters of primary human T cell function in vitro

Grace L. Huang,
Daniel P. Nampe,
Jason Yi,
Grant B. Gabrelow,
Kathleen R. Negri,
Alexander Kamb,
Han Xu

Published: November 9, 2020
https://doi.org/10.1371/journal.pone.0241421

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T cells
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T cell receptors
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Cytotoxicity
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Luciferase assay
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