Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

• Phu N. Tran,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America, Division of Immunology and Hematology Devices, Center for Devices and Radiological Health, US Food and Drug Administration. Silver Spring, Maryland, United States of America

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• Jiansong Sheng,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America, CiPALab, Gaithersburg, Maryland, United States of America

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• Aaron L. Randolph,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Claudia Alvarez Baron,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Nicolas Thiebaud,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America, Vertex Pharmaceuticals (Europe) Ltd, Abingdon, Oxfordshire, United Kingdom

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• Ming Ren,

  Roles Formal analysis, Writing – review & editing

  Affiliation Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Min Wu,

  Roles Formal analysis, Methodology

  Affiliations Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America, Division of Immunology and Hematology Devices, Center for Devices and Radiological Health, US Food and Drug Administration. Silver Spring, Maryland, United States of America

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• Lars Johannesen,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Division of Cardiology and Nephrology, Office of Cardiology, Hematology, Endocrinology and Nephrology, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Donna A. Volpe,

  Roles Resources, Writing – original draft, Writing – review & editing

  Affiliation Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America

  https://orcid.org/0000-0002-8286-9679

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• Dakshesh Patel,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-6507-9771

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• Ksenia Blinova,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, United States of America

  https://orcid.org/0000-0003-1123-3152

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• David G. Strauss,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliation Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Wendy W. Wu

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: wendy.wu@fda.hhs.gov

  Affiliation Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, United States of America

  https://orcid.org/0000-0002-5055-4840

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