Docosahexaenoic acid inhibits the proliferation of Kras/TP53 double mutant pancreatic ductal adenocarcinoma cells through modulation of glutathione level and suppression of nucleotide synthesis

• Wei-Chia Hung ,

  Contributed equally to this work with: Wei-Chia Hung, Der-Yen Lee, En-Pei Isabel Chiang

  Roles Investigation, Methodology

  Affiliation Biomedical Science Laboratory, Department of Nutrition, China Medical University, Taichung, Taiwan, Republic of China

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• Der-Yen Lee ,

  Contributed equally to this work with: Wei-Chia Hung, Der-Yen Lee, En-Pei Isabel Chiang

  Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan, Republic of China

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• En-Pei Isabel Chiang ,

  Contributed equally to this work with: Wei-Chia Hung, Der-Yen Lee, En-Pei Isabel Chiang

  Roles Funding acquisition, Resources, Writing – original draft

  Affiliations Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, Republic of China, Innovation and Development Center of Sustainable Agriculture (IDCSA), National Chung Hsing University, Taichung, Taiwan, Republic of China

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• Jia-Ning Syu,

  Roles Formal analysis, Investigation

  Affiliation Biomedical Science Laboratory, Department of Nutrition, China Medical University, Taichung, Taiwan, Republic of China

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• Che-Yi Chao,

  Roles Visualization

  Affiliations Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, Republic of China, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, Republic of China

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• Mei-Due Yang,

  Roles Funding acquisition, Visualization

  Affiliation Department of Clinical Nutrition and Department of Surgery, China Medical University Hospital, Taichung, Taiwan, Republic of China

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• Shu-Yao Tsai,

  Roles Writing – original draft

  Affiliation Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, Republic of China

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• Feng-Yao Tang

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

  * E-mail: vincenttang@mail.cmu.edu.tw

  Affiliation Biomedical Science Laboratory, Department of Nutrition, China Medical University, Taichung, Taiwan, Republic of China

  https://orcid.org/0000-0002-7861-2643

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