Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis

• Veli Bakalov ,

  Contributed equally to this work with: Veli Bakalov, Laura Reyes-Uribe

  Roles Data curation, Formal analysis, Methodology, Writing – original draft

  Affiliations Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America, Medicine Institute, Allegheny Health Network, Pittsburgh, PA, United States of America

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• Laura Reyes-Uribe ,

  Contributed equally to this work with: Veli Bakalov, Laura Reyes-Uribe

  Roles Data curation, Investigation, Methodology, Writing – original draft

  Affiliation Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America

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• Rahul Deshpande,

  Roles Data curation

  Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Abigail L. Maloy,

  Roles Data curation, Writing – original draft

  Affiliation Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America

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• Steven D. Shapiro,

  Roles Writing – original draft

  Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Derek C. Angus,

  Roles Formal analysis, Writing – original draft

  Affiliation Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America

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• Chung-Chou H. Chang,

  Roles Formal analysis

  Affiliations Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Laurence Le Moyec,

  Roles Formal analysis, Writing – original draft

  Affiliations Université d'Evry Val d'Essonne—Université Paris-Saclay, Evry, France, Muséum National d'Histoire Naturelle, Unité MCAM, UMR7245 CNRS, Paris, France

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• Stacy Gelhaus Wendell,

  Roles Data curation, Formal analysis, Writing – original draft

  Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America

  https://orcid.org/0000-0001-9083-6933

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• Ata Murat Kaynar

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

  * E-mail: kaynar@pitt.edu

  Affiliations Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America, Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America

  https://orcid.org/0000-0001-8847-0450

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