Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids

Grace Woodruff; Naomi Phillips; Cassiano Carromeu; Oivin Guicherit; Alistair White; McCay Johnson; Fabian Zanella; Blake Anson; Timothy Lovenberg; Pascal Bonaventure; Anthony W. Harrington

doi:10.1371/journal.pone.0240991

Loading metrics

Open Access

Peer-reviewed

Research Article

Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids

Grace Woodruff,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Neuroscience Discovery, Janssen Research and Development, LLC., San Diego, California, United States of America

https://orcid.org/0000-0002-7052-1050

⨯
Naomi Phillips,

Roles Data curation, Formal analysis, Investigation

Affiliation Neuroscience Discovery, Janssen Research and Development, LLC., San Diego, California, United States of America
⨯
Cassiano Carromeu,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation StemoniX, Inc, Maple Grove, Minnesota, United States of America
⨯
Oivin Guicherit,

Roles Conceptualization, Writing – review & editing

Affiliation StemoniX, Inc, Maple Grove, Minnesota, United States of America
⨯
Alistair White,

Roles Methodology

Affiliation StemoniX, Inc, Maple Grove, Minnesota, United States of America
⨯
McCay Johnson,

Roles Methodology

Affiliation StemoniX, Inc, Maple Grove, Minnesota, United States of America
⨯
Fabian Zanella,

Roles Conceptualization

Affiliation StemoniX, Inc, Maple Grove, Minnesota, United States of America
⨯
Blake Anson,

Roles Methodology

Affiliation StemoniX, Inc, Maple Grove, Minnesota, United States of America
⨯
Timothy Lovenberg,

Roles Conceptualization

Affiliation Neuroscience Discovery, Janssen Research and Development, LLC., San Diego, California, United States of America
⨯
Pascal Bonaventure,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliation Neuroscience Discovery, Janssen Research and Development, LLC., San Diego, California, United States of America
⨯
Anthony W. Harrington

Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

* E-mail: aharrin1@its.jnj.com

Affiliation Neuroscience Discovery, Janssen Research and Development, LLC., San Diego, California, United States of America
⨯

Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids

Grace Woodruff,
Naomi Phillips,
Cassiano Carromeu,
Oivin Guicherit,
Alistair White,
McCay Johnson,
Fabian Zanella,
Blake Anson,
Timothy Lovenberg,
Pascal Bonaventure

Published: October 22, 2020
https://doi.org/10.1371/journal.pone.0240991

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.
Neurospheres
Is the Subject Area "Neurospheres" applicable to this article?

Thanks for your feedback.
Immune receptors
Is the Subject Area "Immune receptors" applicable to this article?

Thanks for your feedback.
Drug screening
Is the Subject Area "Drug screening" applicable to this article?

Thanks for your feedback.
Neural networks
Is the Subject Area "Neural networks" applicable to this article?

Thanks for your feedback.
Astrocytes
Is the Subject Area "Astrocytes" applicable to this article?

Thanks for your feedback.
Receptor antagonist therapy
Is the Subject Area "Receptor antagonist therapy" applicable to this article?

Thanks for your feedback.
Muscarinic acetylcholine receptors
Is the Subject Area "Muscarinic acetylcholine receptors" applicable to this article?

Thanks for your feedback.