Intranasal GSK2245035, a Toll-like receptor 7 agonist, does not attenuate the allergen-induced asthmatic response in a randomized, double-blind, placebo-controlled experimental medicine study

Hilary Siddall; Diana Quint; Hitesh Pandya; Will Powley; Shaila Shabbir; Jens M. Hohlfeld; Dave Singh; Laurie Lee

doi:10.1371/journal.pone.0240964

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Open Access

Peer-reviewed

Research Article

Intranasal GSK2245035, a Toll-like receptor 7 agonist, does not attenuate the allergen-induced asthmatic response in a randomized, double-blind, placebo-controlled experimental medicine study

Hilary Siddall ,

Roles Data curation, Formal analysis, Methodology, Resources, Supervision, Visualization, Writing – review & editing

* E-mail: hilary.x.siddall@gsk.com

Affiliation Research and development, GSK, Stevenage, Hertfordshire, United Kingdom

https://orcid.org/0000-0002-3134-0855

⨯
Diana Quint,

Roles Conceptualization, Data curation, Methodology, Resources, Visualization, Writing – review & editing

Affiliation Respiratory Therapeutic Area, GSK, Stevenage, Hertfordshire, United Kingdom
⨯
Hitesh Pandya,

Roles Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – review & editing

Current address: Department of Respiratory Sciences, Glenfield Hospital, Leicester, England

Affiliation Respiratory Therapeutic Area, GSK, Stevenage, Hertfordshire, United Kingdom
⨯
Will Powley,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

Affiliation Biostatistics, GSK, Stevenage, Hertfordshire, United Kingdom
⨯
Shaila Shabbir,

Roles Investigation, Project administration, Supervision, Writing – review & editing

Affiliation Immuno-Inflammation Global Clinical Sciences & Delivery, GSK, Stevenage, Hertfordshire, United Kingdom
⨯
Jens M. Hohlfeld,

Roles Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany, Member of the German Center for Lung Research, Hannover, Germany, Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
⨯
Dave Singh,

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

Affiliation Respiratory, Medicines Evaluation Unit, Manchester, United Kingdom
⨯
Laurie Lee

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Clinical development, GSK, Philadelphia, Pennsylvania, United States of America
⨯

Intranasal GSK2245035, a Toll-like receptor 7 agonist, does not attenuate the allergen-induced asthmatic response in a randomized, double-blind, placebo-controlled experimental medicine study

Hilary Siddall,
Diana Quint,
Hitesh Pandya,
Will Powley,
Shaila Shabbir,
Jens M. Hohlfeld,
Dave Singh,
Laurie Lee

Published: November 9, 2020
https://doi.org/10.1371/journal.pone.0240964

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