A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data

Dobril K. Ivanov; Gerrit Bostelmann; Benoit Lan-Leung; Julie Williams; Linda Partridge; Valentina Escott-Price; Janet M. Thornton

doi:10.1371/journal.pone.0240824

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Open Access

Peer-reviewed

Research Article

A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data

Dobril K. Ivanov ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: IvanovD1@cardiff.ac.uk

Affiliations European Molecular Biology Laboratory, The European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, United Kingdom, UK Dementia Research Institute at Cardiff (UKDRI), College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom

https://orcid.org/0000-0001-6271-6301

⨯
Gerrit Bostelmann,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

Affiliation European Molecular Biology Laboratory, The European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, United Kingdom
⨯
Benoit Lan-Leung,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

Affiliation UK Dementia Research Institute at Cardiff (UKDRI), College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom
⨯
Julie Williams,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation UK Dementia Research Institute at Cardiff (UKDRI), College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom
⨯
Linda Partridge ,

Roles Conceptualization, Supervision, Visualization, Writing – review & editing

¶‡ These authors are joint senior authors on this work.

Affiliations Max Planck Institute for Biology of Ageing, Cologne, Germany, Institute of Healthy Ageing, and Department of Genetics, Evolution and Environment, UCL, London, United Kingdom
⨯
Valentina Escott-Price ,

Roles Conceptualization, Methodology, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

¶‡ These authors are joint senior authors on this work.

Affiliation UK Dementia Research Institute at Cardiff (UKDRI), College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom
⨯
Janet M. Thornton

Roles Conceptualization, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

¶‡ These authors are joint senior authors on this work.

Affiliation European Molecular Biology Laboratory, The European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, United Kingdom
⨯

A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data

Dobril K. Ivanov,
Gerrit Bostelmann,
Benoit Lan-Leung,
Julie Williams,
Linda Partridge,
Valentina Escott-Price,
Janet M. Thornton

Published: October 26, 2020
https://doi.org/10.1371/journal.pone.0240824

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Phenotypes
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Drosophila melanogaster
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Microarrays
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Gene ontologies
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Gene expression
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Invertebrate genomics
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