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Open Access

Peer-reviewed

Research Article

Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors

Aiko Murai ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

* E-mail: aiko.murai@takeda.com (AM); shinsuke.araki@takeda.com (SA)

Affiliation Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Shunsuke Ebara,

Roles Data curation, Formal analysis, Methodology

Affiliation Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Satoshi Sasaki,

Roles Methodology, Resources

Affiliation Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Tomohiro Ohashi,

Roles Methodology, Resources

Affiliation Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Tohru Miyazaki,

Roles Methodology, Resources

Affiliation Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Toshiyuki Nomura,

Roles Investigation, Supervision

Affiliation Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Shinsuke Araki

Roles Conceptualization, Data curation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: aiko.murai@takeda.com (AM); shinsuke.araki@takeda.com (SA)

Affiliation Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

https://orcid.org/0000-0002-9936-1417

⨯

Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors

Aiko Murai,
Shunsuke Ebara,
Satoshi Sasaki,
Tomohiro Ohashi,
Tohru Miyazaki,
Toshiyuki Nomura,
Shinsuke Araki

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Published: October 16, 2020
https://doi.org/10.1371/journal.pone.0240718

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Apoptosis
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Cancer treatment
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Cancers and neoplasms
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Breast cancer
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Renal cancer
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Cell cycle and cell division
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Cell growth
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Proteasomes
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