Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1

Sarah Hassan; Jean Peluso; Sandra Chalhoub; Ysia Idoux Gillet; Nadia Benkirane-Jessel; Natacha Rochel; Guy Fuhrmann; Genevieve Ubeaud-Sequier

doi:10.1371/journal.pone.0240676

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Open Access

Peer-reviewed

Research Article

Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1

Sarah Hassan ,

Roles Conceptualization, Methodology, Writing – original draft

* E-mail: sarah.w.hassan@gmail.com

Affiliations Regenerative Nanomedicine, INSERM UMR 1260, FMTS, University of Strasbourg, Strasbourg, France, Platform eBiocyt-UPS1401, Faculty of Pharmacy, University of Strasbourg, Strasbourg, France

http://orcid.org/0000-0002-0025-2895

⨯
Jean Peluso,

Roles Methodology

Affiliation Platform eBiocyt-UPS1401, Faculty of Pharmacy, University of Strasbourg, Strasbourg, France
⨯
Sandra Chalhoub,

Roles Methodology

Affiliation Department of Integrative Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM, U964 CNRS UMR 7104, Université de Strasbourg, Strasbourg, France
⨯
Ysia Idoux Gillet,

Roles Methodology

Affiliation Regenerative Nanomedicine, INSERM UMR 1260, FMTS, University of Strasbourg, Strasbourg, France
⨯
Nadia Benkirane-Jessel,

Roles Supervision

Affiliation Regenerative Nanomedicine, INSERM UMR 1260, FMTS, University of Strasbourg, Strasbourg, France
⨯
Natacha Rochel,

Roles Methodology

Affiliation Department of Integrative Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM, U964 CNRS UMR 7104, Université de Strasbourg, Strasbourg, France
⨯
Guy Fuhrmann,

Roles Supervision, Writing – review & editing

Affiliation Regenerative Nanomedicine, INSERM UMR 1260, FMTS, University of Strasbourg, Strasbourg, France
⨯
Genevieve Ubeaud-Sequier

Roles Supervision, Writing – review & editing

Affiliations Regenerative Nanomedicine, INSERM UMR 1260, FMTS, University of Strasbourg, Strasbourg, France, Platform eBiocyt-UPS1401, Faculty of Pharmacy, University of Strasbourg, Strasbourg, France, Department of Pharmacy, Strasbourg University Hospital, Strasbourg, France
⨯

Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1

Sarah Hassan,
Jean Peluso,
Sandra Chalhoub,
Ysia Idoux Gillet,
Nadia Benkirane-Jessel,
Natacha Rochel,
Guy Fuhrmann,
Genevieve Ubeaud-Sequier

Published: October 14, 2020
https://doi.org/10.1371/journal.pone.0240676

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