Mitigation of liquid–liquid phase separation of a monoclonal antibody by mutations of negative charges on the Fab surface

• Tatsuji Matsuoka ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: matsuoka.tatsuji.bs@daiichisankyo.co.jp

  Current address: Biologics Technology Research Laboratories, Daiichi Sankyo, Co., Ltd., Ohra, Gunma, Japan

  Affiliation Modality Research Laboratories, Daiichi Sankyo, Co., Ltd., Shinagawa, Tokyo, Japan

  https://orcid.org/0000-0001-5982-4248

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• Ryuki Miyauchi,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Modality Research Laboratories, Daiichi Sankyo, Co., Ltd., Shinagawa, Tokyo, Japan

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• Nobumi Nagaoka,

  Roles Data curation, Investigation

  Affiliation Modality Research Laboratories, Daiichi Sankyo, Co., Ltd., Shinagawa, Tokyo, Japan

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• Jun Hasegawa

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing – review & editing

  Current address: Department of Biotechnology, Graduate School of Engineering, Osaka, University, Suita, Osaka, Japan

  Affiliation Modality Research Laboratories, Daiichi Sankyo, Co., Ltd., Shinagawa, Tokyo, Japan

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