Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations

Meriem Laamarti; Tarek Alouane; Souad Kartti; M. W. Chemao-Elfihri; Mohammed Hakmi; Abdelomunim Essabbar; Mohamed Laamarti; Haitam Hlali; Houda Bendani; Nassma Boumajdi; Oussama Benhrif; Loubna Allam; Naima El Hafidi; Rachid El Jaoudi; Imane Allali; Nabila Marchoudi; Jamal Fekkak; Houda Benrahma; Chakib Nejjari; Saaid Amzazi; Lahcen Belyamani; Azeddine Ibrahimi

doi:10.1371/journal.pone.0240345

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Open Access

Peer-reviewed

Research Article

Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations

Meriem Laamarti ,

Contributed equally to this work with: Meriem Laamarti, Tarek Alouane

Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Tarek Alouane ,

Contributed equally to this work with: Meriem Laamarti, Tarek Alouane

Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Souad Kartti,

Roles Formal analysis, Writing – original draft

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco

https://orcid.org/0000-0003-4350-9926

⨯
M. W. Chemao-Elfihri,

Roles Formal analysis, Writing – original draft

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Mohammed Hakmi,

Roles Formal analysis

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Abdelomunim Essabbar,

Roles Data curation

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Mohamed Laamarti,

Roles Resources, Software

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Haitam Hlali,

Roles Resources, Software

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Houda Bendani,

Roles Methodology

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Nassma Boumajdi,

Roles Methodology

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Oussama Benhrif,

Roles Methodology

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Loubna Allam,

Roles Investigation

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Naima El Hafidi,

Roles Supervision

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
Rachid El Jaoudi,

Roles Supervision

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco

https://orcid.org/0000-0002-0692-2036

⨯
Imane Allali,

Roles Formal analysis, Validation

Affiliation Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
⨯
Nabila Marchoudi,

Roles Supervision

Affiliation Anoual Laboratory of Radio-Immuno Analysis, Casablanca, Morocco
⨯
Jamal Fekkak,

Roles Supervision

Affiliation Anoual Laboratory of Radio-Immuno Analysis, Casablanca, Morocco
⨯
Houda Benrahma,

Roles Supervision

Affiliation Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco
⨯
Chakib Nejjari,

Roles Supervision

Affiliation International School of Public Health, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco
⨯
Saaid Amzazi,

Roles Supervision

Affiliation Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
⨯
Lahcen Belyamani,

Roles Supervision

Affiliation Emergency Department, Military Hospital Mohammed V, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco
⨯
[ ... ],
Azeddine Ibrahimi

Roles Conceptualization, Supervision, Validation, Writing – review & editing

* E-mail: a.ibrahimi@um5s.net.ma

Affiliation Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University, Rabat, Morocco

https://orcid.org/0000-0003-3226-3836

⨯
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Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations

Meriem Laamarti,
Tarek Alouane,
Souad Kartti,
M. W. Chemao-Elfihri,
Mohammed Hakmi,
Abdelomunim Essabbar,
Mohamed Laamarti,
Haitam Hlali,
Houda Bendani,
Nassma Boumajdi

Published: November 10, 2020
https://doi.org/10.1371/journal.pone.0240345

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