In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm

• Laura Artigas,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Anaxomics Biotech, Barcelona, Spain

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• Mireia Coma ,

  Roles Conceptualization, Investigation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mcoma@anaxomics.com (MC); baldo.oliva@upf.edu (BO)

  Affiliation Anaxomics Biotech, Barcelona, Spain

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• Pedro Matos-Filipe,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization

  Affiliations Anaxomics Biotech, Barcelona, Spain, Structural Bioinformatics Group, Research Programme on Biomedical Informatics, Department of Experimental and Health Science, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain

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• Joaquim Aguirre-Plans,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Structural Bioinformatics Group, Research Programme on Biomedical Informatics, Department of Experimental and Health Science, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain

  http://orcid.org/0000-0002-1971-1350

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• Judith Farrés,

  Roles Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Anaxomics Biotech, Barcelona, Spain

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• Raquel Valls,

  Roles Data curation, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Anaxomics Biotech, Barcelona, Spain

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• Narcis Fernandez-Fuentes,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biosciences, U Science Tech, Universitat de Vic—Universitat Central de Catalunya, Vic, Catalonia, Spain

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• Juan de la Haba-Rodriguez,

  Roles Conceptualization, Investigation, Resources, Supervision, Writing – review & editing

  Affiliation Maimonides Biomedical Research Institute, Reina Sofia Hospital, University of Cordoba, Cordoba, Spain

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• Alex Olvera,

  Roles Conceptualization, Investigation, Resources, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institut de Recerca de la Sida—IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Badalona (Barcelona), Spain

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• Jose Barbera,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliation Servicio de Medicina interna—Unidad de Infecciosas, La Mancha—Centro Hospital, Alcázar de San Juan, Spain

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• Rafael Morales,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Servicio de Medicina interna—Unidad de Infecciosas, La Mancha—Centro Hospital, Alcázar de San Juan, Spain

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• Baldo Oliva ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mcoma@anaxomics.com (MC); baldo.oliva@upf.edu (BO)

  Affiliation Structural Bioinformatics Group, Research Programme on Biomedical Informatics, Department of Experimental and Health Science, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain

  http://orcid.org/0000-0003-0702-0250

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• Jose Manuel Mas

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Anaxomics Biotech, Barcelona, Spain

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