Nitrate and nitrite exposure leads to mild anxiogenic-like behavior and alters brain metabolomic profile in zebrafish

• Manuel García-Jaramillo ,

  Contributed equally to this work with: Manuel García-Jaramillo, Laura M. Beaver

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: manuel.g.jaramillo@oregonstate.edu

  Affiliations School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America, Department of Chemistry, Oregon State University, Corvallis, Oregon, United States of America, Helfgott Research Institute, National University of Natural Medicine, Portland, Oregon, United States of America

  https://orcid.org/0000-0003-2987-2913

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• Laura M. Beaver ,

  Contributed equally to this work with: Manuel García-Jaramillo, Laura M. Beaver

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

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• Lisa Truong,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Environmental and Molecular Toxicology, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, Oregon, United States of America

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• Elizabeth R. Axton,

  Roles Conceptualization, Investigation, Methodology, Project administration, Writing – review & editing

  Current address: The Jackson Laboratory, Sacramento, California, United States of America

  Affiliations Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America, Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, United States of America

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• Rosa M. Keller,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – review & editing

  Affiliation School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, United States of America

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• Mary C. Prater,

  Roles Investigation, Writing – review & editing

  Current address: Department of Foods and Nutrition, College of Family and Consumer Sciences, University of Georgia, Athens, Georgia, United States of America

  Affiliation School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, United States of America

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• Kathy R. Magnusson,

  Roles Formal analysis, Validation, Writing – review & editing

  Affiliations Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America, Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of America

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• Robyn L. Tanguay,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Department of Environmental and Molecular Toxicology, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, Oregon, United States of America

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• Jan F. Stevens,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Validation, Writing – review & editing

  Affiliations Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America, Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, United States of America

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• Norman G. Hord

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliations School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, United States of America, OU Health, Harold Hamm Diabetes Center, Department of Nutritional Sciences, College of Allied Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

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