PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort

• Aeron M. Small ,

  Contributed equally to this work with: Aeron M. Small, Jennifer E. Huffman

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, United States of America, Department of Medicine, Yale University School of Medicine, New Haven, CT, United States of America

  https://orcid.org/0000-0002-0645-9141

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• Jennifer E. Huffman ,

  Contributed equally to this work with: Aeron M. Small, Jennifer E. Huffman

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliation Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, United States of America

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• Derek Klarin,

  Roles Conceptualization, Formal analysis

  Affiliations Boston VA Healthcare System, Boston, MA, United States of America, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States of America, Department of Surgery, Massachusetts General Hospital, Boston, MA, United States of America

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• Julie A. Lynch,

  Roles Writing – review & editing

  Affiliations Department of Veterans Affairs, Salt Lake City Health Care System, Salt Lake City, UT, United States of America, University of Massachusetts College of Nursing & Health Sciences, Boston, MA, United States of America, Center for Healthcare Organization and Implementation Research, Edith Nourse Rogers Memorial VA Hospital, Bedford, MA, United States of America

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• Themistocles Assimes,

  Roles Conceptualization, Writing – review & editing

  Affiliations Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, United States of America, Stanford University School of Medicine, Stanford, CA, United States of America

  https://orcid.org/0000-0003-2349-0009

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• Scott DuVall,

  Roles Conceptualization, Writing – review & editing

  Affiliations Department of Veterans Affairs, Salt Lake City Health Care System, Salt Lake City, UT, United States of America, Veterans Affairs Informatics and Computing Infrastructure

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• Yan V. Sun,

  Roles Conceptualization, Writing – review & editing

  Affiliations Atlanta VA Health Care System, Decatur, GA, United States of America, Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, United States of America, Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, Unites States of America

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• Labiba Shere,

  Roles Writing – review & editing

  Affiliation Palo Alto Epidemiology Research and Information Center for Genomics, VA Palo Alto Health Care System

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• Pradeep Natarajan,

  Roles Conceptualization, Writing – review & editing

  Affiliations Boston VA Healthcare System, Boston, MA, United States of America, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States of America

  https://orcid.org/0000-0001-8402-7435

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• Michael Gaziano,

  Roles Data curation, Writing – review & editing

  Affiliations Boston VA Healthcare System, Boston, MA, United States of America, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States of America

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• Daniel J. Rader,

  Roles Writing – review & editing

  Affiliation Department of Medicine, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

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• Peter W. F. Wilson,

  Roles Conceptualization, Writing – review & editing

  Affiliations Atlanta VA Health Care System, Decatur, GA, United States of America, Emory Clinical Cardiovascular Research Institute, Atlanta, GA, United States of America

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• Philip S. Tsao,

  Roles Conceptualization, Writing – review & editing

  Affiliations Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, United States of America, Stanford University School of Medicine, Stanford, CA, United States of America

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• Kyong-Mi Chang,

  Roles Conceptualization, Writing – review & editing

  Affiliations Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, United States of America, Department of Medicine, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

  https://orcid.org/0000-0001-6811-9364

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• Kelly Cho,

  Roles Conceptualization, Writing – review & editing

  Affiliation Boston VA Healthcare System, Boston, MA, United States of America

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• Christopher J. O’Donnell,

  Roles Conceptualization, Writing – review & editing

  Affiliations Boston VA Healthcare System, Boston, MA, United States of America, Cardiovascular Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States of America

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• Juan P. Casas,

  Roles Conceptualization, Writing – review & editing

  Affiliation Boston VA Healthcare System, Boston, MA, United States of America

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• Scott M. Damrauer ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

  * E-mail: scott.damrauer@va.gov

  Affiliations Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, United States of America, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

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•  [ ... ],
• on behalf of the VA Million Veteran Program

  ¶Membership of the VA Million Veteran Program is listed in the S1 Data.

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