Human INCL fibroblasts display abnormal mitochondrial and lysosomal networks and heightened susceptibility to ROS-induced cell death

Bailey Balouch; Halle Nagorsky; Truc Pham; James Thai LaGraff; Quynh Chu-LaGraff

doi:10.1371/journal.pone.0239689

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Peer-reviewed

Research Article

Human INCL fibroblasts display abnormal mitochondrial and lysosomal networks and heightened susceptibility to ROS-induced cell death

Bailey Balouch,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Current address: Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

Affiliation Neuroscience Program, Union College, Schenectady, New York, United States of America

https://orcid.org/0000-0002-7016-1374

⨯
Halle Nagorsky,

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Neuroscience Program, Union College, Schenectady, New York, United States of America
⨯
Truc Pham ,

Contributed equally to this work with: Truc Pham, James Thai LaGraff

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Current address: Department of Neurology, Harvard Medical School, Boston Children’s Hospital, Boston, Massachusetts, United States of America

Affiliation Department of Biology, Union College, Schenectady, New York, United States of America
⨯
James Thai LaGraff ,

Contributed equally to this work with: Truc Pham, James Thai LaGraff

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Current address: Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School Boston, Massachusetts, United States of America

Affiliation Department of Biology, Union College, Schenectady, New York, United States of America
⨯
Quynh Chu-LaGraff

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: chulagrq@union.edu

Affiliations Neuroscience Program, Union College, Schenectady, New York, United States of America, Department of Biology, Union College, Schenectady, New York, United States of America

https://orcid.org/0000-0002-3002-3524

⨯

Human INCL fibroblasts display abnormal mitochondrial and lysosomal networks and heightened susceptibility to ROS-induced cell death

Bailey Balouch,
Halle Nagorsky,
Truc Pham,
James Thai LaGraff,
Quynh Chu-LaGraff

Published: February 9, 2021
https://doi.org/10.1371/journal.pone.0239689

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Fibroblasts
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Lysosomes
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