APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development

• Tao Zhang ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization

  ¶‡ Co-first authors who contributed equally to the study.

  Affiliations Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America, University of Delaware, Newark, DE, United States of America, Thomas Jefferson University, Philadelphia, PA, United States of America

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• Koree Ahn ,

  Roles Formal analysis, Investigation, Methodology, Visualization

  ¶‡ Co-first authors who contributed equally to the study.

  Affiliations Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America, University of Delaware, Newark, DE, United States of America, Thomas Jefferson University, Philadelphia, PA, United States of America

  ⨯
• Brooks Emerick,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

  Affiliation Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America

  http://orcid.org/0000-0003-0469-7258

  ⨯
• Shirin R. Modarai,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization

  Affiliations Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America, University of Delaware, Newark, DE, United States of America

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• Lynn M. Opdenaker,

  Roles Data curation, Investigation, Methodology, Resources, Supervision, Visualization

  Affiliations Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America, University of Delaware, Newark, DE, United States of America

  ⨯
• Juan Palazzo,

  Roles Investigation, Resources, Supervision, Visualization

  Affiliation Thomas Jefferson University, Philadelphia, PA, United States of America

  ⨯
• Gilberto Schleiniger,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software

  Affiliation Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America

  ⨯
• Jeremy Z. Fields,

  Roles Formal analysis, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation CATX, Inc., Princeton, NJ, United States of America

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• Bruce M. Boman

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: brboman@udel.edu

  Affiliations Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America, University of Delaware, Newark, DE, United States of America, Thomas Jefferson University, Philadelphia, PA, United States of America, Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America

  http://orcid.org/0000-0002-1335-9149

  ⨯