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Open Access
Peer-reviewed
Research Article
ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models
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Amanda Hanson,
Roles Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliation Preclinical Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Kutlu Elpek,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft
Affiliation Preclinical Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Ellen Duong,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft
Affiliation Preclinical Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
⨯ -
Lindsey Shallberg,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft
Affiliation Preclinical Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
⨯ -
Martin Fan,
Roles Data curation, Formal analysis, Investigation, Methodology
Affiliation Preclinical Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Calvin Johnson,
Roles Data curation, Formal analysis, Investigation, Methodology
Affiliation Preclinical Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Matthew Wallace,
Roles Formal analysis, Investigation, Methodology, Supervision, Writing – original draft
Affiliation Protein Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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George R. Mabry,
Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft
Affiliation Protein Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Stephen Sazinsky,
Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft
Affiliation Protein Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Lauren Pepper,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft
Affiliation Protein Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Chengyi J. Shu,
Roles Data curation, Formal analysis, Methodology, Writing – original draft
Affiliation Translational Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Sriram Sathyanarayanan,
Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – original draft
Affiliation Translational Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Sarah Zuerndorfer,
Roles Data curation, Formal analysis, Investigation, Methodology
Affiliation Protein Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Tyler Simpson,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft
Affiliation Preclinical Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Monica Gostissa,
Roles Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing
Affiliation Pharmacology, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Michael Briskin,
Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing
Affiliation Research, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Deborah Law,
Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing
Affiliation Research, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Jennifer Michaelson,
Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing
Affiliation Preclinical Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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Christopher J. Harvey
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing
* E-mail: charvey@jouncetx.com
Affiliation Preclinical Sciences, Jounce Therapeutics, Inc., Cambridge, Massachusetts, United States of America
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ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models
- Amanda Hanson,
- Kutlu Elpek,
- Ellen Duong,
- Lindsey Shallberg,
- Martin Fan,
- Calvin Johnson,
- Matthew Wallace,
- George R. Mabry,
- Stephen Sazinsky,
- Lauren Pepper
- Published: September 24, 2020
- https://doi.org/10.1371/journal.pone.0239595