CRISPR/Cas9-mediated correction of mutated copper transporter ATP7B

Michael Pöhler; Sarah Guttmann; Oksana Nadzemova; Malte Lenders; Eva Brand; Andree Zibert; Hartmut H. Schmidt; Vanessa Sandfort

doi:10.1371/journal.pone.0239411

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Open Access

Peer-reviewed

Research Article

CRISPR/Cas9-mediated correction of mutated copper transporter ATP7B

Michael Pöhler,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Medizinische Klinik B, Gastroenterologie, Hepatologie, Endokrinologie, Klinische Infektiologie, Universitätsklinikum Münster, Münster, Germany
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Sarah Guttmann,

Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Medizinische Klinik B, Gastroenterologie, Hepatologie, Endokrinologie, Klinische Infektiologie, Universitätsklinikum Münster, Münster, Germany
⨯
Oksana Nadzemova,

Roles Formal analysis, Investigation

Affiliation Medizinische Klinik B, Gastroenterologie, Hepatologie, Endokrinologie, Klinische Infektiologie, Universitätsklinikum Münster, Münster, Germany
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Malte Lenders,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Medizinische Klinik D, Allgemeine Innere Medizin und Notaufnahme sowie Nieren- und Hochdruckkrankheiten und Rheumatologie, Universitätsklinikum Münster, Münster, Germany
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Eva Brand,

Roles Resources

Affiliation Medizinische Klinik D, Allgemeine Innere Medizin und Notaufnahme sowie Nieren- und Hochdruckkrankheiten und Rheumatologie, Universitätsklinikum Münster, Münster, Germany
⨯
Andree Zibert,

Roles Funding acquisition, Project administration, Resources

Affiliation Medizinische Klinik B, Gastroenterologie, Hepatologie, Endokrinologie, Klinische Infektiologie, Universitätsklinikum Münster, Münster, Germany
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Hartmut H. Schmidt,

Roles Funding acquisition, Project administration, Resources, Writing – review & editing

Affiliation Medizinische Klinik B, Gastroenterologie, Hepatologie, Endokrinologie, Klinische Infektiologie, Universitätsklinikum Münster, Münster, Germany
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Vanessa Sandfort

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: Vanessa.Sandfort@ukmuenster.de

Affiliation Medizinische Klinik B, Gastroenterologie, Hepatologie, Endokrinologie, Klinische Infektiologie, Universitätsklinikum Münster, Münster, Germany

http://orcid.org/0000-0001-9934-8848

⨯

CRISPR/Cas9-mediated correction of mutated copper transporter ATP7B

Michael Pöhler,
Sarah Guttmann,
Oksana Nadzemova,
Malte Lenders,
Eva Brand,
Andree Zibert,
Hartmut H. Schmidt,
Vanessa Sandfort

Published: September 30, 2020
https://doi.org/10.1371/journal.pone.0239411

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Point mutation
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Cloning
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Heterozygosity
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DNA repair
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CRISPR
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Liposome-mediated transfection
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