Flavopiridol causes cell cycle inhibition and demonstrates anti-cancer activity in anaplastic thyroid cancer models

• Nicole Pinto,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada, Department of Anatomy and Cell Biology, Western University, London, Ontario, Canada

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• Stephenie D. Prokopec,

  Roles Formal analysis, Writing – review & editing

  Affiliation Ontario Institute for Cancer Research, Toronto, Ontario, Canada

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• Farhad Ghasemi,

  Roles Writing – review & editing

  Affiliation Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada

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• Jalna Meens,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Kara M. Ruicci,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada

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• Imran M. Khan,

  Roles Writing – review & editing

  Affiliation Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada

  http://orcid.org/0000-0003-3020-1324

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• Neil Mundi,

  Roles Writing – review & editing

  Affiliation Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada

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• Krupal Patel,

  Roles Writing – review & editing

  Affiliation Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada

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• Myung W. Han,

  Roles Writing – review & editing

  Affiliation Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada

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• John Yoo,

  Roles Resources, Writing – review & editing

  Affiliations Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada, Department of Oncology, Western University, London, Ontario, Canada

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• Kevin Fung,

  Roles Resources, Writing – review & editing

  Affiliations Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada, Department of Oncology, Western University, London, Ontario, Canada

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• Danielle MacNeil,

  Roles Resources, Writing – review & editing

  Affiliations Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada, Department of Oncology, Western University, London, Ontario, Canada

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• Joe S. Mymryk,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliations Department of Oncology, Western University, London, Ontario, Canada, Department of Microbiology and Immunology, Western University, London, Ontario, Canada

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• Alessandro Datti,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliations Network Biology Collaborative Centre, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Agricultural, Food and Environmental Sciences, University of Perugia, Perugia, Italy

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• John W. Barrett,

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada

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• Paul C. Boutros,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Ontario Institute for Cancer Research, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada, Department of Human Genetics, University of California, Los Angeles, CA, United States of America, Department of Urology, University of California, Los Angeles, CA, United States of America, Broad Stem Cell Research Center, University of California, Los Angeles, CA, United States of America, Institute for Precision Health, University of California, Los Angeles, CA, United States of America, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, United States of America

  http://orcid.org/0000-0003-0553-7520

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• Laurie Ailles ,

  Contributed equally to this work with: Laurie Ailles, Anthony C. Nichols

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliation Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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•  [ ... ],
• Anthony C. Nichols

  Contributed equally to this work with: Laurie Ailles, Anthony C. Nichols

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Anthony.Nichols@lhsc.on.ca

  Affiliations Department of Otolaryngology–Head and Neck Surgery, Western University, London, Ontario, Canada, Department of Oncology, Western University, London, Ontario, Canada

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