Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum

Catiule de Oliveira Santos; Sidnei Ferro Costa; Fabiana Santana Souza; Jessica Mariane Ferreira Mendes; Cristiane Garboggini Melo de Pinheiro; Diogo Rodrigo de Magalhães Moreira; Luciano Kalabric Silva; Valeria Marçal Felix de Lima; Geraldo Gileno de Sá Oliveira

doi:10.1371/journal.pone.0239171

Loading metrics

Open Access

Peer-reviewed

Research Article

Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum

Catiule de Oliveira Santos,

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Laboratory of Structural and Molecular Pathology (LAPEM), Tissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology and Molecular Biology Laboratory (LPBM), Candeal, Salvador, Brazil
⨯
Sidnei Ferro Costa,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Clinical Medicine, Surgery and Animal Reproduction, São Paulo State University (UNESP), School of Veterinary Medicine, Araçatuba, Brazil
⨯
Fabiana Santana Souza,

Roles Formal analysis, Writing – review & editing

Affiliation Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Laboratory of Structural and Molecular Pathology (LAPEM), Tissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology and Molecular Biology Laboratory (LPBM), Candeal, Salvador, Brazil
⨯
Jessica Mariane Ferreira Mendes,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Laboratory of Structural and Molecular Pathology (LAPEM), Tissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology and Molecular Biology Laboratory (LPBM), Candeal, Salvador, Brazil
⨯
Cristiane Garboggini Melo de Pinheiro,

Roles Formal analysis, Investigation, Methodology, Supervision

Affiliation Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Laboratory of Structural and Molecular Pathology (LAPEM), Tissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology and Molecular Biology Laboratory (LPBM), Candeal, Salvador, Brazil
⨯
Diogo Rodrigo de Magalhães Moreira,

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Laboratory of Structural and Molecular Pathology (LAPEM), Tissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology and Molecular Biology Laboratory (LPBM), Candeal, Salvador, Brazil

https://orcid.org/0000-0003-3323-4404

⨯
Luciano Kalabric Silva,

Roles Investigation, Methodology, Software

Affiliation Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Laboratory of Structural and Molecular Pathology (LAPEM), Tissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology and Molecular Biology Laboratory (LPBM), Candeal, Salvador, Brazil
⨯
Valeria Marçal Felix de Lima,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

Affiliation Department of Clinical Medicine, Surgery and Animal Reproduction, São Paulo State University (UNESP), School of Veterinary Medicine, Araçatuba, Brazil
⨯
Geraldo Gileno de Sá Oliveira

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: geraldo.oliveira@fiocruz.br, ggsoliveir@gmail.com

Affiliation Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Laboratory of Structural and Molecular Pathology (LAPEM), Tissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology and Molecular Biology Laboratory (LPBM), Candeal, Salvador, Brazil

https://orcid.org/0000-0001-6065-6480

⨯

Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum

Catiule de Oliveira Santos,
Sidnei Ferro Costa,
Fabiana Santana Souza,
Jessica Mariane Ferreira Mendes,
Cristiane Garboggini Melo de Pinheiro,
Diogo Rodrigo de Magalhães Moreira,
Luciano Kalabric Silva,
Valeria Marçal Felix de Lima,
Geraldo Gileno de Sá Oliveira

Published: January 19, 2021
https://doi.org/10.1371/journal.pone.0239171

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Dogs
Is the Subject Area "Dogs" applicable to this article?

Thanks for your feedback.
Leishmaniasis
Is the Subject Area "Leishmaniasis" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.
Lymphocytes
Is the Subject Area "Lymphocytes" applicable to this article?

Thanks for your feedback.
Leishmania infantum
Is the Subject Area "Leishmania infantum" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Leishmania
Is the Subject Area "Leishmania" applicable to this article?

Thanks for your feedback.
Recombinant proteins
Is the Subject Area "Recombinant proteins" applicable to this article?

Thanks for your feedback.