Hypoxia-induced miR-92a regulates p53 signaling pathway and apoptosis by targeting calcium-sensing receptor in genetically improved farmed tilapia (Oreochromis niloticus)

Jun Qiang; Jie He; Yi-Fan Tao; Jin-Wen Bao; Jun-Hao Zhu; Pao Xu

doi:10.1371/journal.pone.0238897

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Open Access

Peer-reviewed

Research Article

Hypoxia-induced miR-92a regulates p53 signaling pathway and apoptosis by targeting calcium-sensing receptor in genetically improved farmed tilapia (Oreochromis niloticus)

Jun Qiang ,

Contributed equally to this work with: Jun Qiang, Jie He

Roles Data curation, Supervision, Writing – original draft

* E-mail: qiangjunn@163.com (JQ); Xup@ffrc.cn (PX)

Affiliation Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, Jiangsu, China

https://orcid.org/0000-0003-4718-6618

⨯
Jie He ,

Contributed equally to this work with: Jun Qiang, Jie He

Roles Supervision, Writing – review & editing

Affiliation Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, Jiangsu, China
⨯
Yi-Fan Tao,

Roles Formal analysis, Validation

Affiliation Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, Jiangsu, China
⨯
Jin-Wen Bao,

Roles Methodology, Validation

Affiliation Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, Jiangsu, China
⨯
Jun-Hao Zhu,

Roles Methodology, Validation

Affiliation Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, Jiangsu, China
⨯
Pao Xu

Roles Project administration, Supervision, Writing – review & editing

* E-mail: qiangjunn@163.com (JQ); Xup@ffrc.cn (PX)

Affiliation Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, Jiangsu, China
⨯

Hypoxia-induced miR-92a regulates p53 signaling pathway and apoptosis by targeting calcium-sensing receptor in genetically improved farmed tilapia (Oreochromis niloticus)

Jun Qiang,
Jie He,
Yi-Fan Tao,
Jin-Wen Bao,
Jun-Hao Zhu,
Pao Xu

Published: November 12, 2020
https://doi.org/10.1371/journal.pone.0238897

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Hypoxia
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MicroRNAs
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Hepatocytes
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Aquatic hypoxia
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Gene regulation
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