PFRED: A computational platform for siRNA and antisense oligonucleotides design

• Simone Sciabola ,

  Contributed equally to this work with: Simone Sciabola, Robert V. Stanton

  Roles Conceptualization, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Medicinal Chemistry, Biogen, Cambridge, MA, United States of America

  https://orcid.org/0000-0003-1448-3608

  ⨯
• Hualin Xi ,

  Roles Conceptualization, Methodology, Software

  ¶‡ These authors also contributed equally to this work.

  Affiliation Rgenta, Cambridge, MA, United States of America

  ⨯
• Dario Cruz ,

  Roles Software

  ¶‡ These authors also contributed equally to this work.

  Affiliations Medicinal Chemistry, Biogen, Cambridge, MA, United States of America, Chemical Engineering, Northeastern University, Boston, MA, United States of America

  ⨯
• Qing Cao ,

  Roles Conceptualization, Methodology, Software

  ¶‡ These authors also contributed equally to this work.

  Affiliation Medicinal Chemistry, Ra Pharmaceuticals, Cambridge, MA, United States of America

  ⨯
• Christine Lawrence,

  Roles Software

  Affiliation Business Technology, Pfizer, Cambridge, MA, United States of America

  ⨯
• Tianhong Zhang ,

  Roles Software

  ¶‡ These authors also contributed equally to this work.

  Affiliation Business Technology, Pfizer, Cambridge, MA, United States of America

  ⨯
• Sergio Rotstein,

  Roles Resources, Supervision

  Affiliation Business Technology, Pfizer, Cambridge, MA, United States of America

  ⨯
• Jason D. Hughes,

  Roles Conceptualization, Methodology

  Affiliation Computational Biology, Foundation Medicine, Cambridge, MA, United States of America

  ⨯
• Daniel R. Caffrey,

  Roles Conceptualization, Methodology

  Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States of America

  ⨯
• Robert V. Stanton

  Contributed equally to this work with: Simone Sciabola, Robert V. Stanton

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Robert.Stanton@pfizer.com

  Affiliation Simulation and Modeling Sciences, Pfizer, Cambridge, MA, United States of America

  ⨯