Growth inhibition associated with disruption of the actin cytoskeleton by Latrunculin A in rhabdomyosarcoma cells

Julia Würtemberger; Daria Tchessalova; Carla Regina; Christoph Bauer; Michaela Schneider; Amy J. Wagers; Simone Hettmer

doi:10.1371/journal.pone.0238572

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Open Access

Peer-reviewed

Research Article

Growth inhibition associated with disruption of the actin cytoskeleton by Latrunculin A in rhabdomyosarcoma cells

Julia Würtemberger,

Roles Conceptualization, Investigation, Methodology, Writing – original draft

Affiliation Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany
⨯
Daria Tchessalova,

Roles Investigation, Methodology, Supervision

Affiliation Joslin Diabetes Center, Boston, Massachusetts, United States of America
⨯
Carla Regina,

Roles Data curation, Formal analysis, Resources

Affiliation Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany
⨯
Christoph Bauer,

Roles Formal analysis

Affiliation Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany
⨯
Michaela Schneider,

Roles Formal analysis, Validation

Affiliation Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany
⨯
Amy J. Wagers,

Roles Investigation, Visualization

Affiliations Joslin Diabetes Center, Boston, Massachusetts, United States of America, Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America
⨯
Simone Hettmer

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: simone.hettmer@uniklinik-freiburg.de

Affiliation Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany

http://orcid.org/0000-0003-1709-4448

⨯

Growth inhibition associated with disruption of the actin cytoskeleton by Latrunculin A in rhabdomyosarcoma cells

Julia Würtemberger,
Daria Tchessalova,
Carla Regina,
Christoph Bauer,
Michaela Schneider,
Amy J. Wagers,
Simone Hettmer

Published: September 8, 2020
https://doi.org/10.1371/journal.pone.0238572

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Sarcoma
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Sarcoma cells
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Cytoskeleton
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Actins
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Gene regulation
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Gene expression
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Genetic engineering
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