Increased risk of adverse events in non-cancer patients with chronic and high-dose opioid use—A health insurance claims analysis

• Jakob M. Burgstaller ,

  Contributed equally to this work with: Jakob M. Burgstaller, Ulrike Held

  Roles Conceptualization, Methodology, Supervision, Validation, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations Department of Internal Medicine, Horten Center for Patient Oriented Research and Knowledge Transfer, University of Zurich, Zurich, Switzerland, Institute of Primary Care, University and University Hospital Zürich, Zürich, Switzerland

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• Ulrike Held ,

  Contributed equally to this work with: Jakob M. Burgstaller, Ulrike Held

  Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations Department of Internal Medicine, Horten Center for Patient Oriented Research and Knowledge Transfer, University of Zurich, Zurich, Switzerland, Department of Biostatistics at Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Zurich, Switzerland

  http://orcid.org/0000-0003-3105-5840

  ⨯
• Andri Signorell,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Writing – review & editing

  Affiliation Department of Health Sciences, Helsana, Dübendorf, Switzerland

  ⨯
• Eva Blozik,

  Roles Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliations Institute of Primary Care, University and University Hospital Zürich, Zürich, Switzerland, Department of Health Sciences, Helsana, Dübendorf, Switzerland

  ⨯
• Johann Steurer,

  Roles Conceptualization, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Department of Internal Medicine, Horten Center for Patient Oriented Research and Knowledge Transfer, University of Zurich, Zurich, Switzerland

  ⨯
• Maria M. Wertli

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft

  * E-mail: Maria.Wertli@insel.ch

  Affiliations Department of Internal Medicine, Horten Center for Patient Oriented Research and Knowledge Transfer, University of Zurich, Zurich, Switzerland, Department of General Internal Medicine, Bern University Hospital, University of Bern, Bern, Switzerland

  http://orcid.org/0000-0001-6347-0198

  ⨯