L-arginine effects on cerebrovascular reactivity, perfusion and neurovascular coupling in MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) syndrome

• Lance H. Rodan,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Division of Neurology, Dept. of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

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• Julien Poublanc,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Dept. of Medical Imaging, The Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada

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• Joseph A. Fisher,

  Roles Formal analysis, Resources, Writing – review & editing

  Affiliations Dept. of Anesthesiology, University Health Network, University of Toronto, Toronto, Ontario, Canada, Dept. of Physiology and Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada, The Toronto General Hospital Medical Research Institute, Toronto, Ontario, Canada

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• Olivia Sobczyk,

  Roles Formal analysis, Writing – review & editing

  Affiliation Dept. of Medical Imaging, The Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada

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• David J. Mikulis,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Dept. of Medical Imaging, The Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada

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• Ingrid Tein

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft

  * E-mail: Ingrid.tein@sickkids.ca

  Affiliations Division of Neurology, Dept. of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada, Genetics and Genome Biology Program, The Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada, Dept. of Laboratory Medicine and Pathobiology, The University of Toronto, Toronto, Ontario, Canada

  http://orcid.org/0000-0002-5739-3162

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