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Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs
- Chihiro Yamasaki,
- Yuji Ishida,
- Ami Yanagi,
- Yasumi Yoshizane,
- Yuha Kojima,
- Yuko Ogawa,
- Yutaka Kageyama,
- Yumiko Iwasaki,
- Seiichi Ishida,
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Kazuaki Chayama,
Roles Resources
Affiliation Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Higashihiroshima, Hiroshima, Japan
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Chise Tateno
Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – review & editing
* E-mail: chise.mukaidani@phoenixbio.co.jp
Affiliations PhoenixBio Co., Ltd., Higashi-Hiroshima, Hiroshima, Japan, Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan
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http://orcid.org/0000-0002-5530-5341
Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs
- Chihiro Yamasaki,
- Yuji Ishida,
- Ami Yanagi,
- Yasumi Yoshizane,
- Yuha Kojima,
- Yuko Ogawa,
- Yutaka Kageyama,
- Yumiko Iwasaki,
- Seiichi Ishida,
- Kazuaki Chayama
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- Published: September 11, 2020
- https://doi.org/10.1371/journal.pone.0237809