Physical activity prevents acute inflammation in a gout model by downregulation of TLR2 on circulating neutrophils as well as inhibition of serum CXCL1 and is associated with decreased pain and inflammation in gout patients

• Kyle Jablonski ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

  ¶‡ KJ and NAY share first authorship on this work. NAY and NS are joint senior authors on this work.

  Affiliation Division of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, Unites States of America

  ⨯
• Nicholas A. Young ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ KJ and NAY share first authorship on this work. NAY and NS are joint senior authors on this work.

  Affiliation Division of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, Unites States of America

  http://orcid.org/0000-0002-9323-9437

  ⨯
• Caitlin Henry,

  Roles Data curation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Division of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, Unites States of America

  ⨯
• Kyle Caution,

  Roles Data curation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, United States of America

  ⨯
• Anuradha Kalyanasundaram,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States of America

  ⨯
• Ifeoma Okafor,

  Roles Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Division of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, Unites States of America

  ⨯
• Peter Harb,

  Roles Data curation, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Division of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, Unites States of America

  ⨯
• Emmy Schwarz,

  Roles Conceptualization, Data curation, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, Unites States of America

  ⨯
• Paul Consiglio,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States of America

  ⨯
• Chris M. Cirimotich,

  Roles Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Battelle Biomedical Research Center, West Jefferson, OH, United States of America

  ⨯
• Anna Bratasz,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Small Animal Imaging Core, The Ohio State University Wexner Medical Center, Columbus, OH, United States of America

  ⨯
• Anasuya Sarkar,

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States of America

  ⨯
• Amal O. Amer,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, United States of America

  ⨯
• Wael N. Jarjour,

  Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Division of Immunology and Rheumatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, Unites States of America

  ⨯
• Naomi Schlesinger

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  * E-mail: schlesna@rwjms.rutgers.edu

  ¶‡ KJ and NAY share first authorship on this work. NAY and NS are joint senior authors on this work.

  Affiliation Division of Rheumatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States of America

  ⨯