Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response

Monta Briviba; Laura Ansone; Ivars Silamikelis; Vita Rovite; Ilze Elbere; Laila Silamikele; Ineta Kalnina; Davids Fridmanis; Jelizaveta Sokolovska; Ilze Konrade; Valdis Pirags; Janis Klovins

doi:10.1371/journal.pone.0237400

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Open Access

Peer-reviewed

Research Article

Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response

Monta Briviba,

Roles Investigation, Resources, Visualization, Writing – original draft

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Laura Ansone,

Roles Investigation, Writing – review & editing

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Ivars Silamikelis,

Roles Formal analysis, Visualization, Writing – review & editing

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Vita Rovite,

Roles Resources, Writing – review & editing

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Ilze Elbere,

Roles Resources, Writing – review & editing

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Laila Silamikele,

Roles Resources, Writing – review & editing

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Ineta Kalnina,

Roles Funding acquisition, Writing – review & editing

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Davids Fridmanis,

Roles Resources, Writing – review & editing

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia
⨯
Jelizaveta Sokolovska,

Roles Resources, Writing – review & editing

Affiliation Faculty of Medicine, University of Latvia, Riga, Latvia
⨯
Ilze Konrade,

Roles Resources, Writing – review & editing

Affiliations Latvian Biomedical Research and Study Centre, Riga, Latvia, Faculty of Medicine, Riga Stradins University, Riga, Latvia
⨯
Valdis Pirags,

Roles Conceptualization, Writing – review & editing

Affiliations Latvian Biomedical Research and Study Centre, Riga, Latvia, Faculty of Medicine, University of Latvia, Riga, Latvia
⨯
Janis Klovins

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: Klovins@biomed.lu.lv

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia

http://orcid.org/0000-0001-8362-5505

⨯

Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response

Monta Briviba,
Laura Ansone,
Ivars Silamikelis,
Vita Rovite,
Ilze Elbere,
Laila Silamikele,
Ineta Kalnina,
Davids Fridmanis,
Jelizaveta Sokolovska,
Ilze Konrade

Published: August 11, 2020
https://doi.org/10.1371/journal.pone.0237400

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Gene expression
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Mitochondria
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Small nucleolar RNA
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Transcriptome analysis
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Breast cancer
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Gastrointestinal cancers
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Type 2 diabetes
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RNA sequencing
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