Genome-wide association analysis of pulse wave velocity traits provide new insights into the causal relationship between arterial stiffness and blood pressure

Michael Rode; Andrej Teren; Kerstin Wirkner; Katrin Horn; Holger Kirsten; Markus Loeffler; Markus Scholz; Janne Pott

doi:10.1371/journal.pone.0237237

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Open Access

Peer-reviewed

Research Article

Genome-wide association analysis of pulse wave velocity traits provide new insights into the causal relationship between arterial stiffness and blood pressure

Michael Rode,

Roles Formal analysis, Writing – original draft

Affiliation Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany

http://orcid.org/0000-0003-4880-3294

⨯
Andrej Teren,

Roles Investigation

Affiliations LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany, Heart Center Leipzig, Leipzig, Germany
⨯
Kerstin Wirkner,

Roles Investigation

Affiliation LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
⨯
Katrin Horn,

Roles Data curation, Software

Affiliations Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
⨯
Holger Kirsten,

Roles Software

Affiliations Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
⨯
Markus Loeffler,

Roles Funding acquisition, Investigation, Project administration

Affiliations Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
⨯
Markus Scholz ,

Roles Supervision, Writing – review & editing

* E-mail: markus.scholz@imise.uni-leipzig.de

Affiliations Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany, Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany

http://orcid.org/0000-0002-4059-1779

⨯
Janne Pott

Roles Supervision, Writing – review & editing

Affiliations Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany, Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany
⨯

Genome-wide association analysis of pulse wave velocity traits provide new insights into the causal relationship between arterial stiffness and blood pressure

Michael Rode,
Andrej Teren,
Kerstin Wirkner,
Katrin Horn,
Holger Kirsten,
Markus Loeffler,
Markus Scholz,
Janne Pott

Published: August 13, 2020
https://doi.org/10.1371/journal.pone.0237237

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Blood pressure
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Single nucleotide polymorphisms
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Genetic loci
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Genome-wide association studies
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Stiffness
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