The conventional isoproterenol-induced heart failure model does not consistently mimic the diaphragmatic dysfunction observed in patients

• Ignacio Cabrera-Aguilera,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain, Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain, Department of Human Movement Sciences, School of Kinesiology, Faculty of Health Sciences, Universidad de Talca, Talca, Chile

  http://orcid.org/0000-0003-1060-4601

  ⨯
• Bryan Falcones,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain

  ⨯
• Alicia Calvo-Fernández,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain, Heart Failure Unit, Department of Cardiology, Hospital del Mar, Barcelona, Spain

  ⨯
• Begoña Benito,

  Roles Methodology, Resources, Writing – review & editing

  Affiliations Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain, Cardiology Department, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute (VHIR), Barcelona, Spain, CIBER de Enfermedades Cardiovasculares, Madrid, Spain

  ⨯
• Esther Barreiro,

  Roles Methodology, Writing – review & editing

  Affiliations Respiratory Department, Hospital del Mar and Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra, Barcelona, Spain, CIBER de Enfermedades Respiratorias, Madrid, Spain

  ⨯
• Joaquim Gea,

  Roles Methodology, Writing – review & editing

  Affiliations Respiratory Department, Hospital del Mar and Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra, Barcelona, Spain, CIBER de Enfermedades Respiratorias, Madrid, Spain

  ⨯
• Ramon Farré,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain, CIBER de Enfermedades Respiratorias, Madrid, Spain, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain

  ⨯
• Isaac Almendros,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain, CIBER de Enfermedades Respiratorias, Madrid, Spain, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain

  ⨯
• Núria Farré

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft

  * E-mail: NFarreLopez@parcdesalutmar.cat

  Affiliations Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain, Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain, Heart Failure Unit, Department of Cardiology, Hospital del Mar, Barcelona, Spain

  http://orcid.org/0000-0003-3110-6572

  ⨯