Nonspecific cleavages arising from reconstitution of trypsin under mildly acidic conditions

Ben Niu; Michael Martinelli II; Yang Jiao; Chunlei Wang; Mingyan Cao; Jihong Wang; Eric Meinke

doi:10.1371/journal.pone.0236740

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Open Access

Peer-reviewed

Research Article

Nonspecific cleavages arising from reconstitution of trypsin under mildly acidic conditions

Ben Niu ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

* E-mail: ben.niu1@astrazeneca.com

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America

http://orcid.org/0000-0002-6646-9085

⨯
Michael Martinelli II,

Roles Investigation, Methodology

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America
⨯
Yang Jiao,

Roles Investigation, Methodology

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America

http://orcid.org/0000-0003-0847-4211

⨯
Chunlei Wang,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America
⨯
Mingyan Cao,

Roles Investigation

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America
⨯
Jihong Wang,

Roles Conceptualization, Writing – review & editing

Current address: Viela Bio, Gaithersburg, MD, United States of America

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America
⨯
Eric Meinke

Roles Conceptualization, Investigation

Current address: AveXis, Longmont, CO, United States of America

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America

http://orcid.org/0000-0001-7831-8690

⨯

Nonspecific cleavages arising from reconstitution of trypsin under mildly acidic conditions

Ben Niu,
Michael Martinelli II,
Yang Jiao,
Chunlei Wang,
Mingyan Cao,
Jihong Wang,
Eric Meinke

Published: July 28, 2020
https://doi.org/10.1371/journal.pone.0236740
See the preprint

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